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ESD Knife

An ESD knife (endoscopic submucosal dissection knife) is an electrosurgical knife driven by a high-frequency generator. It is used for en bloc resection of early gastric, esophageal or colorectal neoplasia. The single-use knife marks the resection margin, makes the circumferential incision and dissects the submucosal plane with one device, and it works with the generator the unit already has.

This page is intended for healthcare professionals.

ESD Knife

An electrosurgical knife for endoscopic submucosal dissection (ESD), enabling en-bloc resection of early GI neoplasms.

In which cases?

  • Early gastric, oesophageal or colorectal neoplasia planned for en bloc resection.
  • The circumferential mucosal incision that opens the plane before the dissection starts.
  • Dissection of the submucosal plane under a lesion that a snare cannot take whole.
  • Marking the resection margin around the lesion before the incision is made.

What makes it different?

  • Works with the high-frequency generator the unit already has, so no second generator is needed on the trolley.
  • Insulated tip the cutting element is the only exposed part of the knife.
  • Single-use, so the cutting element is in the same condition at the start of every dissection.
  • Marking, incision and dissection done with one device, so the trolley carries fewer items per case.

Frequently asked questions

What is an ESD knife?

An ESD knife is the electrosurgical knife used for endoscopic submucosal dissection (ESD), driven by a high-frequency generator. ESD is a way of removing early neoplasia of the stomach, esophagus or colorectum in one piece (en bloc) by dissecting the submucosal plane. In this context ESD has nothing to do with electrostatic discharge.

In which steps of the procedure is the ESD knife used?

This page lists marking the resection margin around the lesion before the incision, the circumferential mucosal incision that opens the plane, and dissection of the submucosal plane under a lesion that a polypectomy snare cannot take whole. Marking, incision and dissection are done with one device.

What is the difference between EMR and ESD?

In EMR the lesion is lifted first, then taken with a polypectomy snare loop; a lesion of up to about 20 mm is usually taken in one piece and a larger one piecemeal. In ESD the submucosal plane is dissected with a knife, which lets a lesion that a polypectomy snare cannot take whole come out in one piece. The choice of technique is the physician's.

What equipment does an ESD list need?

The ESD category on this site lists the bipolar system, the ESD knife and the traction clip. The hemoclip closes the resection bed, and Easy Collect brings the resected specimen out. The unit decides its own list.

What are the types of ESD knife, such as the dual knife, IT knife and hook knife?

Dual knife, IT knife and hook knife are well-known names for types of ESD knife, and they describe different tip designs. The tip type, the sizes and the maker of the ESD knife on this page are not published yet, and the page is marked coming soon. The knife works with the high-frequency generator the unit already has. Which knife suits a lesion is the physician's decision.

Can I order an ESD knife in Türkiye, and what is the price?

Not yet. The ESD knife is not available for order in Türkiye, so this page carries no list price either. We can share the product documentation; write to us with the button on this page.

Updated: 09.11.2026

This product is not yet available for order in Türkiye. We can share the product documentation and the published studies.